Human ADRbK1 (Adrenergic Receptor Beta Kinase 1) Sandwich ELISA Kit (STJE0006968)
SPECIFICATIONS
General Information
| Short Description | This ADRbK1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.105ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | GRK2 |
| Gene ID | 156 |
| Uniprot ID | ARBK1_HUMAN |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in peripheral blood leukocytes. |
| Post Translational Modifications | |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light. |
| Protein Name | Beta-Adrenergic Receptor Kinase 1Beta-Ark-1G-Protein Coupled Receptor Kinase 2 |
| Database Links | Reactome: R-HSA-111933Reactome: R-HSA-416476Reactome: R-HSA-418555Reactome: R-HSA-5635838Reactome: R-HSA-8856825 |
| Cellular Localisation | CytoplasmCell MembranePostsynapsePresynapse |
| Alternative ELISA Names | Beta-Adrenergic Receptor Kinase 1 ELISA kitBeta-Ark-1 ELISA kitG-Protein Coupled Receptor Kinase 2 ELISA kitGRK2 ELISA kitADRBK1 ELISA kitBARK ELISA kitBARK1 ELISA kit |
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Information sourced from Uniprot.org