Human ADH5 protein (Recombinant) (His-Tag) (STJP017594)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ADH5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 20% Glycerol 0.1M Nacl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADH5 |
| Gene ID | 128 |
| Uniprot ID | ADHX_HUMAN |
| Accession Number | NP_000662 |
| Immunogen | Human |
| Immunogen Region | 1-374aa |
| Immunogen Sequence |
Additional Info
| Function | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation. |
| Protein Name | Alcohol Dehydrogenase Class-3Alcohol Dehydrogenase 5Alcohol Dehydrogenase Class Chi ChainAlcohol Dehydrogenase Class-IiiGlutathione-Dependent Formaldehyde DehydrogenaseFaldhFdhGsh-FdhS-(Hydroxymethylglutathione Dehydrogenase |
| Database Links | Reactome: R-HSA-71384 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Alcohol Dehydrogenase Class-3 proteinAlcohol Dehydrogenase 5 proteinAlcohol Dehydrogenase Class Chi Chain proteinAlcohol Dehydrogenase Class-Iii proteinGlutathione-Dependent Formaldehyde Dehydrogenase proteinFaldh proteinFdh proteinGsh-Fdh proteinS-(Hydroxymethylglutathione Dehydrogenase proteinADH5 proteinADHX proteinFDH protein |
Information sourced from Uniprot.org