Human Adenylosuccinate lyase/ADSL protein (Recombinant) (His-Tag) (STJP017399)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Adenylosuccinate lyase/ADSL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 40% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADSL |
| Gene ID | 158 |
| Uniprot ID | PUR8_HUMAN |
| Accession Number | NP_000017 |
| Immunogen | Human |
| Immunogen Region | 1-484aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1. |
| Function | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. |
| Protein Name | Adenylosuccinate LyaseAdslAslAdenylosuccinaseAsase |
| Database Links | Reactome: R-HSA-73817 |
| Cellular Localisation | |
| Alternative Protein Names | Adenylosuccinate Lyase proteinAdsl proteinAsl proteinAdenylosuccinase proteinAsase proteinADSL proteinAMPS protein |
Information sourced from Uniprot.org