Human Adenylate kinase 2 protein (Recombinant) (His-Tag) (STJP016412)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Adenylate kinase 2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 2mM DTT, 20% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Specific activity is > 25unit/mg. One unit will convert 2.0 umoles of ADP to ATP + AMP per minute at pH 7.5 at 37C. |
Target Information
| Gene Symbol | AK2 |
| Gene ID | 204 |
| Uniprot ID | KAD2_HUMAN |
| Accession Number | NP_001616.1 |
| Immunogen | Human |
| Immunogen Region | 1-239aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). |
| Function | Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. |
| Protein Name | Adenylate Kinase 2 - MitochondrialAk 2Atp-Amp Transphosphorylase 2Atp -Amp PhosphotransferaseAdenylate Monophosphate Kinase Cleaved Into - Adenylate Kinase 2 - Mitochondrial - N-Terminally Processed |
| Database Links | Reactome: R-HSA-499943 |
| Cellular Localisation | Mitochondrion Intermembrane Space |
| Alternative Protein Names | Adenylate Kinase 2 - Mitochondrial proteinAk 2 proteinAtp-Amp Transphosphorylase 2 proteinAtp -Amp Phosphotransferase proteinAdenylate Monophosphate Kinase Cleaved Into - Adenylate Kinase 2 - Mitochondrial - N-Terminally Processed proteinAK2 proteinADK2 protein |
Information sourced from Uniprot.org