| Function | Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). Isoform 1: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. Isoform 2: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. |
| Protein Name | Peroxisomal Acyl-Coenzyme A Oxidase 1AoxPalmitoyl-Coa OxidasePeroxisomal Fatty Acyl-Coa OxidaseStraight-Chain Acyl-Coa OxidaseScox Cleaved Into - Peroxisomal Acyl-Coa Oxidase 1 - A Chain - Peroxisomal Acyl-Coa Oxidase 1 - B Chain - Peroxisomal Acyl-Coa Oxidase 1 - C Chain |
| Database Links | Reactome: R-HSA-1989781 Q15067-1Reactome: R-HSA-2046106 Q15067-2Reactome: R-HSA-390247 Q15067-2Reactome: R-HSA-9033241Reactome: R-HSA-9033500 |
| Cellular Localisation | Peroxisome |
| Alternative Protein Names | Peroxisomal Acyl-Coenzyme A Oxidase 1 proteinAox proteinPalmitoyl-Coa Oxidase proteinPeroxisomal Fatty Acyl-Coa Oxidase proteinStraight-Chain Acyl-Coa Oxidase proteinScox Cleaved Into - Peroxisomal Acyl-Coa Oxidase 1 - A Chain - Peroxisomal Acyl-Coa Oxidase 1 - B Chain - Peroxisomal Acyl-Coa Oxidase 1 - C Chain proteinACOX1 proteinACOX protein |
Information sourced from Uniprot.org
