Human Acetylcholinesterase/ACHE protein (Recombinant) (His-Tag) (STJP019490)
SPECIFICATIONS
HostHEK293 Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Acetylcholinesterase/ACHE-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Specific activity is > 6, 000 nmol/min/mg, and is defined as the amount of enzyme that cleaves 1.0 nmol acetylthiocholine per minute at pH7.5 at 25C. |
Target Information
| Gene Symbol | ACHE |
| Gene ID | 43 |
| Uniprot ID | ACES_HUMAN |
| Accession Number | NP_000656.1 |
| Immunogen | Human |
| Immunogen Region | 32-614aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Isoform H is highly expressed in erythrocytes. |
| Function | Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis. |
| Protein Name | AcetylcholinesteraseAche |
| Database Links | Reactome: R-HSA-112311Reactome: R-HSA-1483191Reactome: R-HSA-422085 |
| Cellular Localisation | SynapseSecretedCell MembranePeripheral Membrane ProteinIsoform T: NucleusOnly Observed In Apoptotic NucleiIsoform H: Cell MembraneLipid-AnchorGpi-AnchorExtracellular Side |
| Alternative Protein Names | Acetylcholinesterase proteinAche proteinACHE protein |
Information sourced from Uniprot.org