Human ACAN protein (Recombinant) (N-His) (STJP010041)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ACAN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ACAN |
| Gene ID | 176 |
| Uniprot ID | PGCA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu2321-His2530 |
Additional Info
| Post Translational Modifications | Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. |
| Function | This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. |
| Protein Name | Aggrecan Core ProteinCartilage-Specific Proteoglycan Core ProteinCspcpChondroitin Sulfate Proteoglycan Core Protein 1Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022854Reactome: R-HSA-2022857Reactome: R-HSA-3000178Reactome: R-HSA-3656225Reactome: R-HSA-3656243Reactome: R-HSA-3656244 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Aggrecan Core Protein proteinCartilage-Specific Proteoglycan Core Protein proteinCspcp proteinChondroitin Sulfate Proteoglycan Core Protein 1 proteinChondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 proteinACAN proteinAGC1 proteinCSPG1 proteinMSK16 protein |
Information sourced from Uniprot.org