Human ACADL protein (Recombinant) (His-Tag) (STJP017402)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ACADL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 0.15M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACADL |
| Gene ID | 33 |
| Uniprot ID | ACADL_HUMAN |
| Accession Number | NP_001599 |
| Immunogen | Human |
| Immunogen Region | 31-430aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3. |
| Function | Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains. |
| Protein Name | Long-Chain Specific Acyl-Coa Dehydrogenase - MitochondrialLcad |
| Database Links | Reactome: R-HSA-77285Reactome: R-HSA-77288Reactome: R-HSA-77310 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Long-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial proteinLcad proteinACADL protein |
Information sourced from Uniprot.org