Human ACAA2 protein (Recombinant) (His-Tag) (STJP018127)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ACAA2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACAA2 |
| Gene ID | 10449 |
| Uniprot ID | THIM_HUMAN |
| Accession Number | NP_006102 |
| Immunogen | Human |
| Immunogen Region | 17-397 |
| Immunogen Sequence |
Additional Info
| Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage. |
| Protein Name | 3-Ketoacyl-Coa Thiolase - MitochondrialAcetyl-Coa AcetyltransferaseAcetyl-Coa AcyltransferaseAcyl-Coa Hydrolase - MitochondrialBeta-KetothiolaseMitochondrial 3-Oxoacyl-Coa ThiolaseT1 |
| Database Links | Reactome: R-HSA-77289 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | 3-Ketoacyl-Coa Thiolase - Mitochondrial proteinAcetyl-Coa Acetyltransferase proteinAcetyl-Coa Acyltransferase proteinAcyl-Coa Hydrolase - Mitochondrial proteinBeta-Ketothiolase proteinMitochondrial 3-Oxoacyl-Coa Thiolase proteinT1 proteinACAA2 protein |
Information sourced from Uniprot.org