Human ABHD2 protein (Recombinant) (N-His) (STJP008237)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABHD2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABHD2 |
| Gene ID | 11057 |
| Uniprot ID | ABHD2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala40-Glu425 |
Additional Info
| Function | Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration. |
| Protein Name | Monoacylglycerol Lipase Abhd22-Arachidonoylglycerol HydrolaseAbhydrolase Domain-Containing Protein 2AcetylesteraseLung Alpha/Beta Hydrolase 2Progesterone-Sensitive LipaseProtein Phps1-2 |
| Database Links | |
| Cellular Localisation | Cell ProjectionCiliumFlagellum MembraneSingle-Pass Type Ii Membrane ProteinCell Membrane |
| Alternative Protein Names | Monoacylglycerol Lipase Abhd2 protein2-Arachidonoylglycerol Hydrolase proteinAbhydrolase Domain-Containing Protein 2 proteinAcetylesterase proteinLung Alpha/Beta Hydrolase 2 proteinProgesterone-Sensitive Lipase proteinProtein Phps1-2 proteinABHD2 proteinLABH2 protein |
Information sourced from Uniprot.org