Human ABCD4 protein (Recombinant) (N-His) (STJP003191)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABCD4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABCD4 |
| Gene ID | 5826 |
| Uniprot ID | ABCD4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu356-Glu606 |
Additional Info
| Function | Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane. |
| Protein Name | Lysosomal Cobalamin Transporter Abcd4Atp-Binding Cassette Sub-Family D Member 4Pmp70-Related ProteinP70rPeroxisomal Membrane Protein 1-LikePxmp1-LPeroxisomal Membrane Protein 69Pmp69 |
| Database Links | Reactome: R-HSA-5683329Reactome: R-HSA-9758881Reactome: R-HSA-9758890 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLysosome MembraneTargeted By Lmbrd1 Lysosomal Chaperone To The Lysosomal Membrane |
| Alternative Protein Names | Lysosomal Cobalamin Transporter Abcd4 proteinAtp-Binding Cassette Sub-Family D Member 4 proteinPmp70-Related Protein proteinP70r proteinPeroxisomal Membrane Protein 1-Like proteinPxmp1-L proteinPeroxisomal Membrane Protein 69 proteinPmp69 proteinABCD4 proteinPXMP1L protein |
Information sourced from Uniprot.org