Human ABCC2 (ATP Binding Cassette Transporter C2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013196)
SPECIFICATIONS
General Information
| Short Description | This ABCC2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.067ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | ABCC2 |
| Gene ID | 1244 |
| Uniprot ID | MRP2_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver. Expressed in small intestine. |
| Post Translational Modifications | |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 2 Canalicular Multidrug Resistance ProteinCanalicular Multispecific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2 |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-382556Reactome: R-HSA-5679001Reactome: R-HSA-9749641Reactome: R-HSA-9753281Reactome: R-HSA-9754706 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalized To The Apical Membrane Of Enterocytes |
| Alternative ELISA Names | Atp-Binding Cassette Sub-Family C Member 2 ELISA kitCanalicular Multidrug Resistance Protein ELISA kitCanalicular Multispecific Organic Anion Transporter 1 ELISA kitMultidrug Resistance-Associated Protein 2 ELISA kitABCC2 ELISA kitCMOAT ELISA kitCMOAT1 ELISA kitCMRP ELISA kitMRP2 ELISA kit |
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Information sourced from Uniprot.org