Human ABCC11 (ATP Binding Cassette Transporter C11) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013193)
SPECIFICATIONS
General Information
| Short Description | This ABCC11 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.103ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | ABCC11 |
| Gene ID | 85320 |
| Uniprot ID | MRP8_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Expressed in apocrine glands (at protein level). Expressed at moderate levels in breast and testis and at very low levels in liver, brain and placenta. Localizes to axons of the central and peripheral nervous system (at protein level). |
| Post Translational Modifications | |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides, including cAMP and cGMP. Mediates the ATP-dependent efflux of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates, such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Plays a role in the transport of earwax components. Participates in the secretion of odorants and their precursors from the apocrine sweat glands, including the secretion of glutamine conjugates, as well as the Cys-Gly-(S) conjugates of 3-methyl-3-sulfanyl-hexanol. Involved in the cellular extrusion of nucleotide analogs, hence confering resistance to various drugs, including clinically relevant drugs such as 5-fluorouracil (5-FU) and methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 11Multidrug Resistance-Associated Protein 8 |
| Database Links | Reactome: R-HSA-382556 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinVacuole MembraneCytoplasmic Vesicle MembraneApical Cell Membrane |
| Alternative ELISA Names | Atp-Binding Cassette Sub-Family C Member 11 ELISA kitMultidrug Resistance-Associated Protein 8 ELISA kitABCC11 ELISA kitMRP8 ELISA kit |
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Information sourced from Uniprot.org