Human ABCB8 protein (Recombinant) (N-His) (STJP006090)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABCB8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABCB8 |
| Gene ID | 11194 |
| Uniprot ID | MITOS_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val472-Ser735 |
Additional Info
| Function | ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes. |
| Protein Name | Mitochondrial Potassium Channel Atp-Binding SubunitAtp-Binding Cassette Sub-Family B Member 8 - MitochondrialAbcb8Mitochondrial Atp-Binding Cassette 1M-Abc1Mitochondrial Sulfonylurea-ReceptorMitosur |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Mitochondrial Potassium Channel Atp-Binding Subunit proteinAtp-Binding Cassette Sub-Family B Member 8 - Mitochondrial proteinAbcb8 proteinMitochondrial Atp-Binding Cassette 1 proteinM-Abc1 proteinMitochondrial Sulfonylurea-Receptor proteinMitosur proteinABCB8 proteinMABC1 proteinMITOSUR protein |
Information sourced from Uniprot.org