Human ABCB6 protein (Recombinant) (N-His) (STJP006036)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABCB6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABCB6 |
| Gene ID | 10058 |
| Uniprot ID | ABCB6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile590-Arg842 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 6Abc-Type Heme Transporter Abcb6Mitochondrial Abc Transporter 3Mt-Abc Transporter 3P-Glycoprotein-Related ProteinUbiquitously-Expressed Mammalian Abc Half Transporter |
| Database Links | Reactome: R-HSA-1369007Reactome: R-HSA-5683371 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion Outer MembraneEndoplasmic Reticulum MembraneGolgi Apparatus MembraneEndosome MembraneLysosome MembraneLate Endosome MembraneEarly Endosome MembraneSecretedExtracellular ExosomeMitochondrionEndosomeMultivesicular Body MembraneMelanosome MembranePresent In The Membrane Of Mature Erythrocytes And In Exosomes Released From Reticulocytes During The Final Steps Of Erythroid MaturationTraffics From Endoplasmic Reticulum To Golgi During Its Glycans's MaturationTherefrom Is First Targeted To The Plasma MembraneAnd Is Rapidly Internalized Through Endocytosis To Be Distributed To The Limiting Membrane Of Multivesicular Bodies And LysosomesLocalized On The Limiting Membrane Of Early Melanosomes Of Pigment CellsTargeted To The Endolysosomal Compartment |
| Alternative Protein Names | Atp-Binding Cassette Sub-Family B Member 6 proteinAbc-Type Heme Transporter Abcb6 proteinMitochondrial Abc Transporter 3 proteinMt-Abc Transporter 3 proteinP-Glycoprotein-Related Protein proteinUbiquitously-Expressed Mammalian Abc Half Transporter proteinABCB6 proteinMTABC3 proteinPRP proteinUMAT protein |
Information sourced from Uniprot.org