Human ABCB11 protein (Recombinant) (N-His) (STJP003421)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABCB11-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABCB11 |
| Gene ID | 8647 |
| Uniprot ID | ABCBB_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu421-Ala663 |
Additional Info
| Post Translational Modifications | N-glycosylated. Ubiquitinated.short-chain ubiquitination regulates cell-Surface expression of ABCB11. |
| Function | Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion. |
| Protein Name | Bile Salt Export PumpAtp-Binding Cassette Sub-Family B Member 11 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-193368Reactome: R-HSA-5678520 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneEndosomeCell MembraneInternalized At The Canalicular Membrane Through Interaction With The Adapter Protein Complex 2 (Ap-2)At Steady StateLocalizes In The Canalicular Membrane But Is Also Present In Recycling EndosomesAbcb11 Constantly And Rapidly Exchanges Between The Two Sites Through Tubulo-Vesicles Carriers That Move Along MicrotubulesMicrotubule-Dependent Trafficking Of Abcb11 Is Enhanced By Taurocholate And Camp And Regulated By Stk11 Through A Pka-Mediated PathwayTrafficking Of Newly Synthesized Abcb11 Through Endosomal Compartment To The Bile Canalicular Membrane Is Accelerated By Camp But Not By TaurocholateCell Membrane Expression Is Up-Regulated By Short- And Medium-Chain Fatty Acids |
| Alternative Protein Names | Bile Salt Export Pump proteinAtp-Binding Cassette Sub-Family B Member 11 proteinABCB11 proteinBSEP protein |
Information sourced from Uniprot.org