Human ABCA7 protein (Recombinant) (N-His) (STJP008047)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABCA7-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABCA7 |
| Gene ID | 10347 |
| Uniprot ID | ABCA7_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp1773-Asp2121 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylserine over phosphatidylcholine. Plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocyte differentiation. Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. Plays a role in phagocytosis of apoptotic cells by macrophages. Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7. Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages. Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing. Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients. |
| Protein Name | Phospholipid-Transporting Atpase Abca7Abca-SsnAtp-Binding Cassette Sub-Family A Member 7Autoantigen Ss-NMacrophage Abc Transporter |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneEarly Endosome MembraneCytoplasmCell ProjectionRuffle MembranePhagocytic CupLocalizes To Cell Membrane Ruffles And Phagocytic Cups Of Macrophages Stimulated With C1q Or Apoptotic CellsLocalizes To The Cytoplasm Of Resting MacrophagesProbably In Golgi And EndosomesLocalizes To The Apical Brush Border Of Cells In The Proximal Tubules Of KidneyIsoform 2: CytoplasmEndoplasmic ReticulumMay Localize To The Endoplasmic Reticulum |
| Alternative Protein Names | Phospholipid-Transporting Atpase Abca7 proteinAbca-Ssn proteinAtp-Binding Cassette Sub-Family A Member 7 proteinAutoantigen Ss-N proteinMacrophage Abc Transporter proteinABCA7 protein |
Information sourced from Uniprot.org