Human ABCA1 protein (Recombinant) (N-His) (STJP003433)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABCA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABCA1 |
| Gene ID | 19 |
| Uniprot ID | ABCA1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser45-Glu271 |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylated by ZDHHC8. Palmitoylation is essential for localization to the plasma membrane. |
| Function | Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. |
| Protein Name | Phospholipid-Transporting Atpase Abca1Atp-Binding Cassette Sub-Family A Member 1Atp-Binding Cassette Transporter 1Abc-1Atp-Binding Cassette 1Cholesterol Efflux Regulatory Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-5682113Reactome: R-HSA-8963896Reactome: R-HSA-9029569 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome |
| Alternative Protein Names | Phospholipid-Transporting Atpase Abca1 proteinAtp-Binding Cassette Sub-Family A Member 1 proteinAtp-Binding Cassette Transporter 1 proteinAbc-1 proteinAtp-Binding Cassette 1 proteinCholesterol Efflux Regulatory Protein proteinABCA1 proteinABC1 proteinCERP protein |
Information sourced from Uniprot.org