Human A2ML1 protein (Recombinant) (N-His) (STJP003119)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human A2ML1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | A2ML1 |
| Gene ID | 144568 |
| Uniprot ID | A2ML1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln1119-Thr1348 |
Additional Info
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. |
| Protein Name | Alpha-2-Macroglobulin-Like Protein 1C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 9 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Alpha-2-Macroglobulin-Like Protein 1 proteinC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 9 proteinA2ML1 proteinCPAMD9 protein |
Information sourced from Uniprot.org