Human A1CF protein (Recombinant) (N-His) (STJP006064)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human A1CF-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | A1CF |
| Gene ID | 29974 |
| Uniprot ID | A1CF_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly389-Arg587 |
Additional Info
| Function | Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. |
| Protein Name | Apobec1 Complementation FactorApobec1-Stimulating Protein |
| Database Links | Reactome: R-HSA-72200Reactome: R-HSA-75094 |
| Cellular Localisation | NucleusEndoplasmic ReticulumCytoplasmPredominantly Nuclear Where It Localizes To HeterochromatinAlso Cytoplasmic Where It Is Found At The Outer Surface Of The Endoplasmic ReticulumShuttles Between The Nucleus And CytoplasmMay Be Transported Into The Nucleus By The Nuclear Import Protein Tnpo2/Trn2 Or By Apobec1 |
| Alternative Protein Names | Apobec1 Complementation Factor proteinApobec1-Stimulating Protein proteinA1CF proteinACF proteinASP protein |
Information sourced from Uniprot.org