Human 4E-BP3/EIF4EBP3 protein (Recombinant) (His-Tag) (STJP018868)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human 4E-BP3/EIF4EBP3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EIF4EBP3 |
| Gene ID | 8637 |
| Uniprot ID | 4EBP3_HUMAN |
| Accession Number | NP_003723 |
| Immunogen | Human |
| Immunogen Region | 1-100aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMSTSTSC PIPGGRDQLP DCYSTTPGGT LYATTPGGTR IIYDRKFLLE CKNSPIARTP PCCLPQIPGV TTPPTAPLSK LEELKEQETE EEIPDDAQFE MDI |
Additional Info
| Tissue Specificity | Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. |
| Post Translational Modifications | Phosphorylated. |
| Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e-Binding Protein 34e-Bp3Eif4e-Binding Protein 3 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Eukaryotic Translation Initiation Factor 4e-Binding Protein 3 protein4e-Bp3 proteinEif4e-Binding Protein 3 proteinEIF4EBP3 protein |
Information sourced from Uniprot.org