Glucose Transporter GLUT1 Blocking Peptide peptide (STJ504137)

SKU:
STJ504137-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Glucose Transporter GLUT1 Blocking Peptide is synthetically produced from the 478-492 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC2A1
Gene ID: 6513
Uniprot ID: GTR1_HUMAN
Immunogen Region: 478-492
Immunogen: Synthetic peptide conjugated to KLH, corresponding to amino acids 478-492 of Human Glucose Transporter GLUT1. Peptide was covalently modified. Sequence: PEELFHPLGADSQV
Tissue Specificity Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.
Post Translational Modifications Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.
Function Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity.can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation.
Peptide Name Solute Carrier Family 2 - Facilitated Glucose Transporter Member 1
Glucose Transporter Type 1 - Erythrocyte/Brain
Glut-1
Hepg2 Glucose Transporter
Database Links Reactome: R-HSA-189200
Reactome: R-HSA-196836
Reactome: R-HSA-422356
Reactome: R-HSA-5619043
Reactome: R-HSA-5653890
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Melanosome
Photoreceptor Inner Segment
Localizes Primarily At The Cell Surface
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Peptide Names Solute Carrier Family 2 - Facilitated Glucose Transporter Member 1 protein
Glucose Transporter Type 1 - Erythrocyte/Brain protein
Glut-1 protein
Hepg2 Glucose Transporter protein
SLC2A1 protein
GLUT1 protein

Information sourced from Uniprot.org

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