Glucose Transporter 8 Blocking Peptide is synthetically produced from the 400-500 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 400-500 on GLUT8 protein.
Immunogen Region
400-500
Additional Info
Tissue Specificity
Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.
Function
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate.
Peptide Name
Solute Carrier Family 2 - Facilitated Glucose Transporter Member 8Glucose Transporter Type 8Glut-8Glucose Transporter Type X1
Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembranePrincipally IntracellularMay Move Between Intracellular Vesicles And The Plasma MembraneThe Dileucine Internalization Motif Is Critical For Intracellular Sequestration
Alternative Peptide Names
Solute Carrier Family 2 - Facilitated Glucose Transporter Member 8 proteinGlucose Transporter Type 8 proteinGlut-8 proteinGlucose Transporter Type X1 proteinSLC2A8 proteinGLUT8 proteinGLUTX1 protein
