| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | GBA Blocking Peptide for STJ501178 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | GBA1 |
| Gene ID: | 2629 |
| Uniprot ID: | GBA1_HUMAN |
| Specificity: | This blocking peptide is recommended for use in combination with GBA antibody, STJ501178 |
| Immunogen: | Recombinant Glucosylceramidase protein. |
| Function | Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (Probable). Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside. |
| Peptide Name | Lysosomal Acid Glucosylceramidase Lysosomal Acid Gcase Acid Beta-Glucosidase Alglucerase Beta-Glucocerebrosidase Beta-Gc Beta-Glucosylceramidase 1 Cholesterol Glucosyltransferase Sgtase Cholesteryl-Beta-Glucosidase D-Glucosyl-N-Acylsphingosine Glucohydrolase Glucosylceramidase Beta 1 Imiglucerase Lysosomal Cholesterol Glycosyltransferase Lysosomal Galactosylceramidase Lysosomal Glycosylceramidase |
| Database Links | Reactome: R-HSA-390471 Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome Membrane Peripheral Membrane Protein Lumenal Side Interaction With Saposin-C Promotes Membrane Association Targeting To Lysosomes Occurs Through An Alternative Mpr-Independent Mechanism Via Scarb2 |
| Alternative Peptide Names | Lysosomal Acid Glucosylceramidase protein Lysosomal Acid Gcase protein Acid Beta-Glucosidase protein Alglucerase protein Beta-Glucocerebrosidase protein Beta-Gc protein Beta-Glucosylceramidase 1 protein Cholesterol Glucosyltransferase protein Sgtase protein Cholesteryl-Beta-Glucosidase protein D-Glucosyl-N-Acylsphingosine Glucohydrolase protein Glucosylceramidase Beta 1 protein Imiglucerase protein Lysosomal Cholesterol Glycosyltransferase protein Lysosomal Galactosylceramidase protein Lysosomal Glycosylceramidase protein GBA1 protein GBA protein GC protein GLUC protein |
Information sourced from Uniprot.org