| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Galectin 3 Blocking Peptide is synthetically produced from the 150-250 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | LGALS3 |
| Gene ID: | 3958 |
| Uniprot ID: | LEG3_HUMAN |
| Immunogen Region: | 150-250 |
| Immunogen: | C-epitope synthetic peptide taken within amino acid sequences 150-250 on human Galectin 3 protein. |
| Tissue Specificity | A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. |
| Function | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. |
| Peptide Name | Galectin-3 Gal-3 35 Kda Lectin Carbohydrate-Binding Protein 35 Cbp 35 Galactose-Specific Lectin 3 Galactoside-Binding Protein Galbp Ige-Binding Protein L-31 Laminin-Binding Protein Lectin L-29 Mac-2 Antigen |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-879415 Reactome: R-HSA-8939246 Reactome: R-HSA-8941333 |
| Cellular Localisation | Cytoplasm Nucleus Secreted Secreted By A Non-Classical Secretory Pathway And Associates With The Cell Surface Can Be Secreted The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Peptide Names | Galectin-3 protein Gal-3 protein 35 Kda Lectin protein Carbohydrate-Binding Protein 35 protein Cbp 35 protein Galactose-Specific Lectin 3 protein Galactoside-Binding Protein protein Galbp protein Ige-Binding Protein protein L-31 protein Laminin-Binding Protein protein Lectin L-29 protein Mac-2 Antigen protein LGALS3 protein MAC2 protein |
Information sourced from Uniprot.org