Galectin 3 Blocking Peptide peptide (STJ503777)

SKU:
STJ503777-250

$390.83
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Galectin 3 Blocking Peptide is synthetically produced from the 150-250 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: LGALS3
Gene ID: 3958
Uniprot ID: LEG3_HUMAN
Immunogen Region: 150-250
Immunogen: C-epitope synthetic peptide taken within amino acid sequences 150-250 on human Galectin 3 protein.
Tissue Specificity A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Peptide Name Galectin-3
Gal-3
35 Kda Lectin
Carbohydrate-Binding Protein 35
Cbp 35
Galactose-Specific Lectin 3
Galactoside-Binding Protein
Galbp
Ige-Binding Protein
L-31
Laminin-Binding Protein
Lectin L-29
Mac-2 Antigen
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-879415
Reactome: R-HSA-8939246
Reactome: R-HSA-8941333
Cellular Localisation Cytoplasm
Nucleus
Secreted
Secreted By A Non-Classical Secretory Pathway And Associates With The Cell Surface
Can Be Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative Peptide Names Galectin-3 protein
Gal-3 protein
35 Kda Lectin protein
Carbohydrate-Binding Protein 35 protein
Cbp 35 protein
Galactose-Specific Lectin 3 protein
Galactoside-Binding Protein protein
Galbp protein
Ige-Binding Protein protein
L-31 protein
Laminin-Binding Protein protein
Lectin L-29 protein
Mac-2 Antigen protein
LGALS3 protein
MAC2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance