FOLR1 Positive Control for STJ501071 peptide (STJ505521)
SPECIFICATIONS
General Information
| Short Description | FOLR1 Positive Control for STJ501071 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Folr1 |
| Gene ID | 14275 |
| Uniprot ID | FOLR1_MOUSE |
| Specificity | This is positive control is recommended for use in combination with FOLR1 antibody STJ501071. |
Additional Info
| Tissue Specificity | Detected in kidney proximal tubules (at protein level). |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. |
| Peptide Name | Folate Receptor AlphaFr-AlphaFolate Receptor 1Folate-Binding Protein 1 |
| Database Links | Reactome: R-MMU-204005Reactome: -MMU-5694530Reactome: -MMU-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Peptide Names | Folate Receptor Alpha proteinFr-Alpha proteinFolate Receptor 1 proteinFolate-Binding Protein 1 proteinFolr1 proteinFbp1 proteinFolbp1 protein |
Information sourced from Uniprot.org