Filamin B Blocking Peptide peptide (Phospho) (2481) (STJ505693)

SKU:
STJ505693-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-Filamin B Blocking Peptide is synthetically produced from the 2450-2500 sequence about the 2481 and is suitable for use in western blot applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: FLNB
Gene ID: 2317
Uniprot ID: FLNB_HUMAN
Immunogen Region: 2450-2500
Immunogen: Synthetic peptide taken within amino acid region 2450-2500 on human Phospho-Filamin-B. Phosphorylated 2481 serine residue.
Tissue Specificity Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.
Post Translational Modifications ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 1 leads to proteasomal degradation which promotes muscle differentiation.
Function Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Peptide Name Filamin-B
Fln-B
Abp-278
Abp-280 Homolog
Actin-Binding-Like Protein
Beta-Filamin
Filamin Homolog 1
Fh1
Filamin-3
Thyroid Autoantigen
Truncated Actin-Binding Protein
Truncated Abp
Database Links Reactome: R-HSA-1169408
Cellular Localisation Isoform 1: Cytoplasm
Cell Cortex
Cytoplasm
Cytoskeleton
Stress Fiber
Myofibril
Sarcomere
Z Line
In Differentiating Myotubes
Isoform 1
Isoform 2 And Isoform 3 Are Localized Diffusely Throughout The Cytoplasm With Regions Of Enrichment At The Longitudinal Actin Stress Fiber
In Differentiated Tubes
Isoform 1 Is Also Detected Within The Z-Lines
Isoform 2: Cytoplasm
Isoform 3: Cytoplasm
Isoform 6: Cytoplasm
Polarized At The Periphery Of Myotubes
Alternative Peptide Names Filamin-B protein
Fln-B protein
Abp-278 protein
Abp-280 Homolog protein
Actin-Binding-Like Protein protein
Beta-Filamin protein
Filamin Homolog 1 protein
Fh1 protein
Filamin-3 protein
Thyroid Autoantigen protein
Truncated Actin-Binding Protein protein
Truncated Abp protein
FLNB protein
FLN1L protein
FLN3 protein
TABP protein
TAP protein

Information sourced from Uniprot.org

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