EPAC1 Blocking Peptide is synthetically produced from the 520-560 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 520-560 on Exchange Protein Directly Activated by cAMP protein.
Immunogen Region
520-560
Additional Info
Tissue Specificity
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Function
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Peptide Name
Rap Guanine Nucleotide Exchange Factor 3Exchange Factor Directly Activated By Camp 1Exchange Protein Directly Activated By Camp 1Epac 1Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CampCamp-Regulated Guanine Nucleotide Exchange Factor ICamp-Gefi
