EPAC1 Blocking Peptide peptide (STJ504008)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 5-50 on Exchange Protein Directly Activated by cAMP protein.
General Information
| Short Description | EPAC1 Blocking Peptide is synthetically produced from the 5-50 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | RAPGEF3 |
| Gene ID | 10411 |
| Uniprot ID | RPGF3_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 5-50 on Exchange Protein Directly Activated by cAMP protein. |
| Immunogen Region | 5-50 |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
| Peptide Name | Rap Guanine Nucleotide Exchange Factor 3Exchange Factor Directly Activated By Camp 1Exchange Protein Directly Activated By Camp 1Epac 1Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CampCamp-Regulated Guanine Nucleotide Exchange Factor ICamp-Gefi |
| Database Links | Reactome: R-HSA-354192Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-422356 |
| Cellular Localisation | Endomembrane System |
| Alternative Peptide Names | Rap Guanine Nucleotide Exchange Factor 3 proteinExchange Factor Directly Activated By Camp 1 proteinExchange Protein Directly Activated By Camp 1 proteinEpac 1 proteinRap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp proteinCamp-Regulated Guanine Nucleotide Exchange Factor I proteinCamp-Gefi proteinRAPGEF3 proteinCGEF1 proteinEPAC proteinEPAC1 protein |
Information sourced from Uniprot.org