ENT1 Blocking Peptide for STJ500884 is synthetically produced from the 410-460 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid reigon 410-460 on mouse Equilibrative nitrobenzylthioinosine-sensitive nucleoside transporter ENT1 protein.
Immunogen Region
410-460
Specificity
This blocking peptide is recommended for use in combination with ENT1 antibody, STJ500884
Additional Info
Tissue Specificity
Highly expressed in heart, spleen, lung, liver and testis. Lower level of expression in brain and kidney. Expressed in adipose tissues, brown adipocytes expressing significantly higher amounts than white adipocytes. Expressed in seminiferous tubules.
Post Translational Modifications
Glycosylated.
Function
Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier. Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure.
Peptide Name
Equilibrative Nucleoside Transporter 1Ment1Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside TransporterEquilibrative Nbmpr-Sensitive Nucleoside TransporterNucleoside Transporter - Es-TypeSolute Carrier Family 29 Member 1
