| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
EHD3 Blocking Peptide is synthetically produced from the 525-555 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
EHD3 |
| Gene ID: |
30845 |
| Uniprot ID: |
EHD3_HUMAN |
| Immunogen Region: |
525-555 |
| Immunogen: |
Synthetic peptide taken within amino acid region 525-555 on human EH-domain containing protein 3. |
| Tissue Specificity | Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta. |
| Function | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor. Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction. In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function. Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis.possibly sharing redundant functions with EHD1. |
| Peptide Name | Eh Domain-Containing Protein 3Past Homolog 3 |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | Recycling Endosome MembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCell ProjectionCilium MembraneLocalizes To The Ciliary Pocket From Where The Cilium ProtrudesColocalizes With Rab8a And Myo5b To A Cytoplasmic Tubular Network Devoid Of Rab11aColocalizes With Ank2 In Myocyte Perinuclear RegionColocalizes With Bace1 In Tubulovesicular Cytoplasmic MembranesColocalizes With Bace1 And App Amyloid Beta Proteins In Hippocampal Mossy Fiber Terminals |
| Alternative Peptide Names | Eh Domain-Containing Protein 3 proteinPast Homolog 3 proteinEHD3 proteinEHD2 proteinPAST3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
