| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
EAAT2 Blocking Peptide is synthetically produced from the 550-574 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SLC1A2 |
| Gene ID: |
6506 |
| Uniprot ID: |
EAA2_HUMAN |
| Immunogen Region: |
550-574 |
| Immunogen: |
Synthetic peptide corresponding to C terminal amino acids 550-574 of Human EAAT2. Sequence: KVTLAANGKSADCSVEEEPWKREK |
| Post Translational Modifications | Glycosylated. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. |
| Peptide Name | Excitatory Amino Acid Transporter 2Glutamate/Aspartate Transporter IiSodium-Dependent Glutamate/Aspartate Transporter 2Solute Carrier Family 1 Member 2 |
| Database Links | Reactome: R-HSA-210455Reactome: R-HSA-210500Reactome: R-HSA-425393 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Excitatory Amino Acid Transporter 2 proteinGlutamate/Aspartate Transporter Ii proteinSodium-Dependent Glutamate/Aspartate Transporter 2 proteinSolute Carrier Family 1 Member 2 proteinSLC1A2 proteinEAAT2 proteinGLT1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
