| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Dnmt3b Positive Control for STJ506259 is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Dnmt3b |
| Gene ID: |
13436 |
| Uniprot ID: |
DNM3B_MOUSE |
| Immunogen Region: |
50-100 |
| Specificity: |
This is positive control is recommended for use in combination with Dnmt3b antibody STJ506259. |
| Function | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells. |
| Peptide Name | DnaCytosine-5-Methyltransferase 3bDnmt3bDna Methyltransferase MmuiiibDna Mtase MmuiiibM.mmuiiib |
| Database Links | Reactome: R-MMU-212300Reactome: -MMU-4655427 |
| Cellular Localisation | NucleusAccumulates In The Major Satellite Repeats At Pericentric Heterochromatin |
| Alternative Peptide Names | Dna proteinCytosine-5-Methyltransferase 3b proteinDnmt3b proteinDna Methyltransferase Mmuiiib proteinDna Mtase Mmuiiib proteinM.mmuiiib proteinDnmt3b protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
