DCC Blocking Peptide for STJ500740 peptide (STJ503948)

SKU:
STJ503948-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: DCC Blocking Peptide for STJ500740 is synthetically produced from the 1330-1380 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: DCC
Gene ID: 1630
Uniprot ID: DCC_HUMAN
Immunogen Region: 1330-1380
Specificity: This blocking peptide is recommended for use in combination with DCC antibody, STJ500740
Immunogen: Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.
Tissue Specificity Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
Post Translational Modifications Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Peptide Name Netrin Receptor Dcc
Colorectal Cancer Suppressor
Immunoglobulin Superfamily Dcc Subclass Member 1
Tumor Suppressor Protein Dcc
Database Links Reactome: R-HSA-373752
Reactome: R-HSA-376172
Reactome: R-HSA-418885
Reactome: R-HSA-418886
Reactome: R-HSA-418889
Reactome: R-HSA-418890
Reactome: R-HSA-428542
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Peptide Names Netrin Receptor Dcc protein
Colorectal Cancer Suppressor protein
Immunoglobulin Superfamily Dcc Subclass Member 1 protein
Tumor Suppressor Protein Dcc protein
DCC protein
IGDCC1 protein

Information sourced from Uniprot.org

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