DAPK2 Positive Control for STJ500730 peptide (STJ505697)
SPECIFICATIONS
ImmunogenPurified Death-associated protein kinase 2 protein.
General Information
| Short Description | DAPK2 Positive Control for STJ500730 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:2, 500-1:5, 000 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Dapk2 |
| Gene ID | 13143 |
| Uniprot ID | DAPK2_MOUSE |
| Immunogen | Purified Death-associated protein kinase 2 protein. |
| Specificity | This is positive control is recommended for use in combination with DAPK2 antibody STJ500730. |
Additional Info
| Tissue Specificity | Expressed in peritubular interstitial cells of the renal cortex. Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level). |
| Post Translational Modifications | Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors. |
| Function | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytes motility by controlling cell spreading and polarization. |
| Peptide Name | Death-Associated Protein Kinase 2Dap Kinase 2Dap-Kinase-Related Protein 1Drp-1 |
| Cellular Localisation | CytoplasmCytoplasmic VesicleAutophagosome Lumen |
| Alternative Peptide Names | Death-Associated Protein Kinase 2 proteinDap Kinase 2 proteinDap-Kinase-Related Protein 1 proteinDrp-1 proteinDapk2 protein |
Information sourced from Uniprot.org