DAPK2 Blocking Peptide for STJ500731 peptide (STJ505696)

Name: DAPK2 Blocking Peptide for STJ500731 peptide (STJ505696)
SKU: STJ505696-250
Price: 260.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ImmunogenSynthetic peptide take within amino acid region 300-350 on mouse Death-associated protein kinase 2 protein.

STJ505696-250

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Short Description	DAPK2 Blocking Peptide for STJ500731 is synthetically produced from the 300-350 sequence and is suitable for use in western blot applications.
Applications	Immunodepletion/Immunocompetition
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	Dapk2
Gene ID	13143
Uniprot ID	DAPK2_MOUSE
Immunogen	Synthetic peptide take within amino acid region 300-350 on mouse Death-associated protein kinase 2 protein.
Immunogen Region	300-350
Specificity	This blocking peptide is recommended for use in combination with DAPK2 antibody, STJ500731

Tissue Specificity	Expressed in peritubular interstitial cells of the renal cortex. Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level).
Post Translational Modifications	Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activated Fas and TNF-alpha receptors.
Function	Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytes motility by controlling cell spreading and polarization.
Peptide Name	Death-Associated Protein Kinase 2 Dap Kinase 2 Dap-Kinase-Related Protein 1 Drp-1
Cellular Localisation	Cytoplasm Cytoplasmic Vesicle Autophagosome Lumen
Alternative Peptide Names	Death-Associated Protein Kinase 2 protein Dap Kinase 2 protein Dap-Kinase-Related Protein 1 protein Drp-1 protein Dapk2 protein

Information sourced from Uniprot.org