D4S234E Positive Control for STJ501973 is synthetically produced from the sequence and is suitable for use in western blot applications.
Applications
WB
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Dilution Range
WB: 1:500
Formulation
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
This is positive control is recommended for use in combination with D4S234E antibody STJ501973.
Additional Info
Tissue Specificity
Widely expressed in brain and spinal cord. Expressed in neurons during maturation and synapse formation.
Function
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
Peptide Name
Neuronal Vesicle Trafficking-Associated Protein 1Brain Neuron Cytoplasmic Protein 1/2Neuron-Enriched Endosomal Protein Of 21 KdaNeuron-Specific Protein Family Member 1
Cellular Localisation
MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneEndosome MembraneCell ProjectionDendriteEarly Endosome MembraneLate Endosome MembraneLysosome LumenRecycling Endosome MembraneCytoplasmic Vesicle MembraneGolgi Stack MembraneEndosomeMultivesicular Body MembraneEndoplasmic Reticulum MembraneEndocytosed From The Cell SurfaceThus Enters Into Early EndosomesTrafficks To Late Endosomes And Degradates In LysosomesEndoplasmic Reticulum Targeting Is Essential For ApoptosisFound In Both Stationary And Motile EndosomesA Previous Study Supports A Type I Membrane Protein Topology
Alternative Peptide Names
Neuronal Vesicle Trafficking-Associated Protein 1 proteinBrain Neuron Cytoplasmic Protein 1/2 proteinNeuron-Enriched Endosomal Protein Of 21 Kda proteinNeuron-Specific Protein Family Member 1 proteinNsg1 proteinBsmrb protein
