D4S234E Blocking Peptide for STJ501974 is synthetically produced from the 140-190 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 140-190 on human Neuron-specific protein family member 1.
Immunogen Region
140-190
Specificity
This blocking peptide is recommended for use in combination with D4S234E antibody, STJ501974
Additional Info
Tissue Specificity
Widely expressed in brain and spinal cord. Expressed in neurons during maturation and synapse formation.
Function
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
Peptide Name
Neuronal Vesicle Trafficking-Associated Protein 1Brain Neuron Cytoplasmic Protein 1/2Neuron-Enriched Endosomal Protein Of 21 KdaNeuron-Specific Protein Family Member 1
Cellular Localisation
MembraneSingle-Pass Type Ii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneEndosome MembraneCell ProjectionDendriteEarly Endosome MembraneLate Endosome MembraneLysosome LumenRecycling Endosome MembraneCytoplasmic Vesicle MembraneGolgi Stack MembraneEndosomeMultivesicular Body MembraneEndoplasmic Reticulum MembraneEndocytosed From The Cell SurfaceThus Enters Into Early EndosomesTrafficks To Late Endosomes And Degradates In LysosomesEndoplasmic Reticulum Targeting Is Essential For ApoptosisFound In Both Stationary And Motile EndosomesA Previous Study Supports A Type I Membrane Protein Topology
Alternative Peptide Names
Neuronal Vesicle Trafficking-Associated Protein 1 proteinBrain Neuron Cytoplasmic Protein 1/2 proteinNeuron-Enriched Endosomal Protein Of 21 Kda proteinNeuron-Specific Protein Family Member 1 proteinNsg1 proteinBsmrb protein
