| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CXCR2 Positive Control for STJ500651 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Cxcr2 |
| Gene ID: |
12765 |
| Uniprot ID: |
CXCR2_MOUSE |
| Specificity: |
This is positive control is recommended for use in combination with CXCR2 antibody STJ500651. |
| Post Translational Modifications | Phosphorylated upon ligand binding.which is required for desensitization. |
| Function | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
| Peptide Name | C-X-C Chemokine Receptor Type 2Cxc-R2Cxcr-2Gro/Mgsa ReceptorHigh Affinity Interleukin-8 Receptor BIl-8r BCd Antigen Cd182 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | C-X-C Chemokine Receptor Type 2 proteinCxc-R2 proteinCxcr-2 proteinGro/Mgsa Receptor proteinHigh Affinity Interleukin-8 Receptor B proteinIl-8r B proteinCd Antigen Cd182 proteinCxcr2 proteinCmkar2 proteinGpcr16 proteinIl8rb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
