| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CXCR2 Blocking Peptide for STJ506205 is synthetically produced from the 445-538 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Cxcr2 |
| Gene ID: |
12765 |
| Uniprot ID: |
CXCR2_MOUSE |
| Immunogen Region: |
445-538 |
| Specificity: |
This blocking peptide is recommended for use in combination with CXCR2 antibody, STJ506205 |
| Immunogen: |
Synthetic peptide corresponding to amino acids within region 445-538 on mouse C-X-C Chemokine Receptot type 2. |
| Post Translational Modifications | Phosphorylated upon ligand binding.which is required for desensitization. |
| Function | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
| Peptide Name | C-X-C Chemokine Receptor Type 2Cxc-R2Cxcr-2Gro/Mgsa ReceptorHigh Affinity Interleukin-8 Receptor BIl-8r BCd Antigen Cd182 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | C-X-C Chemokine Receptor Type 2 proteinCxc-R2 proteinCxcr-2 proteinGro/Mgsa Receptor proteinHigh Affinity Interleukin-8 Receptor B proteinIl-8r B proteinCd Antigen Cd182 proteinCxcr2 proteinCmkar2 proteinGpcr16 proteinIl8rb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
