| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CRMP2 Blocking Peptide is synthetically produced from the 60-115 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
DPYSL2 |
| Gene ID: |
1808 |
| Uniprot ID: |
DPYL2_HUMAN |
| Immunogen Region: |
60-115 |
| Immunogen: |
Synthetic peptide taken from within the region corresponding to AA 60-115 of the CRMP2 protein. The 26mer peptide was conserved in several other species. The selected peptide was post-synthetically modified to achieve highest antigenicity before coup |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. |
| Function | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. |
| Peptide Name | Dihydropyrimidinase-Related Protein 2Drp-2Collapsin Response Mediator Protein 2Crmp-2N2a3Unc-33-Like Phosphoprotein 2Ulip-2 |
| Database Links | Reactome: R-HSA-399956Reactome: R-HSA-437239 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMembraneTightly But Non-Covalently Associated With Membranes |
| Alternative Peptide Names | Dihydropyrimidinase-Related Protein 2 proteinDrp-2 proteinCollapsin Response Mediator Protein 2 proteinCrmp-2 proteinN2a3 proteinUnc-33-Like Phosphoprotein 2 proteinUlip-2 proteinDPYSL2 proteinCRMP2 proteinULIP2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
