CHMP2B Blocking Peptide is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 200-250 on human Vacuolar-sorting Protein SNF8 protein.
Immunogen Region
200-250
Additional Info
Function
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan.
Peptide Name
Vacuolar-Sorting Protein Snf8Ell-Associated Protein Of 30 KdaEscrt-Ii Complex Subunit Vps22Hvps22
CytoplasmEndosome MembraneNucleusLate Endosome MembraneRecruited To The Endosome Membrane To Participate In Vesicle Formation
Alternative Peptide Names
Vacuolar-Sorting Protein Snf8 proteinEll-Associated Protein Of 30 Kda proteinEscrt-Ii Complex Subunit Vps22 proteinHvps22 proteinSNF8 proteinEAP30 protein
