| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Chimaerin beta 2 Positive Control for STJ502195 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
CHN2 |
| Gene ID: |
1124 |
| Uniprot ID: |
CHIO_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with Chimaerin beta 2 antibody STJ502195. |
| Tissue Specificity | Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas. |
| Function | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| Peptide Name | Beta-ChimaerinBeta-ChimerinRho Gtpase-Activating Protein 3 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | MembranePeripheral Membrane Protein |
| Alternative Peptide Names | Beta-Chimaerin proteinBeta-Chimerin proteinRho Gtpase-Activating Protein 3 proteinCHN2 proteinARHGAP3 proteinBCH protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
