CGRP Positive Control for STJ506114 peptide (STJ505839)
SPECIFICATIONS
General Information
| Short Description | CGRP Positive Control for STJ506114 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500-1:5, 000 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Calca |
| Gene ID | 12310 |
| Uniprot ID | CALCA_MOUSE |
| Specificity | This is positive control is recommended for use in combination with CGRP antibody STJ506114. |
Additional Info
| Tissue Specificity | Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. |
| Function | CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex. |
| Peptide Name | Calcitonin Gene-Related Peptide 1Cgrp1Alpha-Type CgrpCalcitonin Gene-Related Peptide ICgrp-I |
| Database Links | Reactome: R-MMU-418555Reactome: -MMU-419812 |
| Cellular Localisation | Secreted |
| Alternative Peptide Names | Calcitonin Gene-Related Peptide 1 proteinCgrp1 proteinAlpha-Type Cgrp proteinCalcitonin Gene-Related Peptide I proteinCgrp-I proteinCalca proteinCalc protein |
Information sourced from Uniprot.org