CGRP Blocking Peptide for STJ506112 peptide (STJ505838)
SPECIFICATIONS
ImmunogenSynthetic peptide corresponding to amino acids within region 350-410 mouse Calcitonin gene-related peptide 1.
General Information
| Short Description | CGRP Blocking Peptide for STJ506112 is synthetically produced from the 350-410 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Calca |
| Gene ID | 12310 |
| Uniprot ID | CALCA_MOUSE |
| Immunogen | Synthetic peptide corresponding to amino acids within region 350-410 mouse Calcitonin gene-related peptide 1. |
| Immunogen Region | 350-410 |
| Specificity | This blocking peptide is recommended for use in combination with CGRP antibody, STJ506112 |
Additional Info
| Tissue Specificity | Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult. |
| Function | CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex. |
| Peptide Name | Calcitonin Gene-Related Peptide 1Cgrp1Alpha-Type CgrpCalcitonin Gene-Related Peptide ICgrp-I |
| Database Links | Reactome: R-MMU-418555Reactome: -MMU-419812 |
| Cellular Localisation | Secreted |
| Alternative Peptide Names | Calcitonin Gene-Related Peptide 1 proteinCgrp1 proteinAlpha-Type Cgrp proteinCalcitonin Gene-Related Peptide I proteinCgrp-I proteinCalca proteinCalc protein |
Information sourced from Uniprot.org