CDNF protein (STJP000138)
SPECIFICATIONS
General Information
| Short Description | CDNF-protein was developed from. For use in research applications. |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/ml |
| Purification | Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter |
| Formulation | PBS pH 7.4 |
| Storage Instruction | Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
Target Information
| Gene Symbol | CDNF |
| Gene ID | 441549 |
| Uniprot ID | CDNF_HUMAN |
Additional Info
| Tissue Specificity | Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. |
| Function | Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. |
| Protein Name | Cerebral Dopamine Neurotrophic FactorArmet-Like Protein 1Conserved Dopamine Neurotrophic Factor |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Cerebral Dopamine Neurotrophic Factor proteinArmet-Like Protein 1 proteinConserved Dopamine Neurotrophic Factor proteinCDNF proteinARMETL1 protein |
Information sourced from Uniprot.org