| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | CD39 Positive Control for STJ500889 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:2, 500-1:5, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ENTPD1 |
| Gene ID: | 953 |
| Uniprot ID: | ENTP1_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with CD39 antibody STJ500889. |
| Immunogen: | EctoNucleoside TriPhosphate Diphosphohydrolase 1 purified protein. |
| Tissue Specificity | Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Highly expressed in placenta, lung, skeletal muscle, kidney. |
| Post Translational Modifications | N-glycosylated. The N-terminus is blocked. Palmitoylated on Cys-13.which is required for caveola targeting. |
| Function | Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow. |
| Peptide Name | Ectonucleoside Triphosphate Diphosphohydrolase 1 Atp Diphosphohydrolase Atp-Dph Atpdase Ecto-Atp Diphosphohydrolase 1 Ecto-Atpdase 1 Ecto-Atpase 1 Ecto-Apyrase Lymphoid Cell Activation Antigen Nucleoside Triphosphate Diphosphohydrolase 1 Ntpdase1 Cd Antigen Cd39 |
| Database Links | Reactome: R-HSA-8850843 Reactome: R-HSA-9660826 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Caveola |
| Alternative Peptide Names | Ectonucleoside Triphosphate Diphosphohydrolase 1 protein Atp Diphosphohydrolase protein Atp-Dph protein Atpdase protein Ecto-Atp Diphosphohydrolase 1 protein Ecto-Atpdase 1 protein Ecto-Atpase 1 protein Ecto-Apyrase protein Lymphoid Cell Activation Antigen protein Nucleoside Triphosphate Diphosphohydrolase 1 protein Ntpdase1 protein Cd Antigen Cd39 protein ENTPD1 protein CD39 protein |
Information sourced from Uniprot.org