| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
CCK4 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
MAP3K12 |
| Gene ID: |
7786 |
| Uniprot ID: |
M3K12_HUMAN |
| Immunogen: |
Purified Protein tyrosine kinase 7 protein was emulsified in complete adjuvant and used to immunize the rabbits. |
| Tissue Specificity | Highly expressed in brain and kidney. |
| Post Translational Modifications | Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. |
| Function | Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. |
| Peptide Name | Mitogen-Activated Protein Kinase Kinase Kinase 12Dual Leucine Zipper Bearing KinaseDlkLeucine-Zipper Protein KinaseZpkMapk-Upstream KinaseMukMixed Lineage Kinase |
| Cellular Localisation | CytoplasmCell MembraneBehaves Essentially As An Integral Membrane Protein |
| Alternative Peptide Names | Mitogen-Activated Protein Kinase Kinase Kinase 12 proteinDual Leucine Zipper Bearing Kinase proteinDlk proteinLeucine-Zipper Protein Kinase proteinZpk proteinMapk-Upstream Kinase proteinMuk proteinMixed Lineage Kinase proteinMAP3K12 proteinZPK protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
