CCDC98 Positive Control for STJ500026 peptide (STJ503618)
General Information
| Short Description | CCDC98 Positive Control for STJ500026 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ABRAXAS1 |
| Gene ID | 84142 |
| Uniprot ID | ABRX1_HUMAN |
| Specificity | This is positive control is recommended for use in combination with CCDC98 antibody STJ500026. |
Additional Info
| Post Translational Modifications | Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage. |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Peptide Name | Brca1-A Complex Subunit Abraxas 1Coiled-Coil Domain-Containing Protein 98Protein Fam175a |
| Database Links | Reactome: R-HSA-5689901Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-69473 |
| Cellular Localisation | NucleusLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Peptide Names | Brca1-A Complex Subunit Abraxas 1 proteinCoiled-Coil Domain-Containing Protein 98 proteinProtein Fam175a proteinABRAXAS1 proteinABRA1 proteinCCDC98 proteinFAM175A proteinUNQ496 proteinPRO1013 protein |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about CCDC98 Positive Control for STJ500026 peptide (STJ503618)
This is a positive control reagent intended for use in combination with the CCDC98 antibody STJ500026. It is designed to confirm antibody performance and validate western blot results for CCDC98 detection.
This positive control corresponds to the CCDC98 protein, referenced by UniProt accession Q6UWZ7.
This product is supplied as 100 uL ready-to-use in SDS-PAGE sample buffer (Laemmli buffer) containing Tris pH 6.8, 1% SDS, glycerol, and bromophenol blue as a tracking dye. The sample is reduced with 2% beta-mercaptoethanol, and the protein concentration is empirically adjusted to produce a clear band with an appropriate signal-to-noise ratio for use with its corresponding antibody.
This positive control is validated for use in western blot (WB) only.
No additional preparation is required. The product is supplied ready-to-use and pre-reduced, so it can be loaded directly onto an SDS-PAGE gel without further processing.
This product should be stored at -20 degrees Celsius for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain product integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.