CCAR1 Positive Control for STJ500385 peptide (STJ505501)
SPECIFICATIONS
General Information
| Short Description | CCAR1 Positive Control for STJ500385 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | WB |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | WB: 1:500 |
| Formulation | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | CCAR1 |
| Gene ID | 55749 |
| Uniprot ID | CCAR1_HUMAN |
| Specificity | This is positive control is recommended for use in combination with CCAR1 antibody STJ500385. |
Additional Info
| Tissue Specificity | Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. |
| Function | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells. |
| Peptide Name | Cell Division Cycle And Apoptosis Regulator Protein 1Cell Cycle And Apoptosis Regulatory Protein 1Carp-1Death Inducer With Sap Domain |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Peptide Names | Cell Division Cycle And Apoptosis Regulator Protein 1 proteinCell Cycle And Apoptosis Regulatory Protein 1 proteinCarp-1 proteinDeath Inducer With Sap Domain proteinCCAR1 proteinCARP1 proteinDIS protein |
Information sourced from Uniprot.org